Action Of Drugs On The Cerebellar Electrical Activities

A detailed analysis of the action of 1762 IS was made. The usual pharmacological procedures were used as well as a more specific technique which included a study of the modifications of the electrical activity at the various levels of the cerebro-spinal axis, the effects of the application to the cerebral and cerebellar cortex of the substance on the cortical electrical activity and its action on spinal integratory mechanisms. In preliminary toxicity studies, a synthetic compound, 4-formyl-4-phenylN-methyl-piperidine (1762 IS) showed convulsant properties very similar to those of strychnine. More detailed neuropharmacological investigations dealing with the action of 1762 IS on the cerebral electrical activity, on the mono-and polysnaptic reflexes and on the 'primary' spinal inhibition have confirmed the similarities between this compound and strychnine. Some relationships between structure and pharmacological properties are discussed. (Author).

This second edition of 'Seizures and Epilepsy' is completely revised, due to tremendous advances in the understanding of the fundamental neuronal mechanisms underlying epileptic phenomena, as well as current diagnosis and treatment, which have been heavily influenced over the past several decades by seminal neuroscientific developments, particularly the introduction of molecular neurobiology, genetics, and modern neuroimaging. This resource covers a broad range of both basic and clinical epileptology.

This book covers stereotactic principles as well as functional stereotaxis, covering the history and uses of the techniques, treatments for specific conditions, and future developments. Includes a DVD demonstrating surgical procedures.